Overview
This appointment is to work within the laboratory of Professor Sundrud and will focus on the local regulation of mucosal T cell function by bile acids in the small intestine. The Sundrud lab has recently demonstrated that circulating T cells sense and respond to the presence of locally-reabsorbed bile acids in the ileum to maintain homeostasis and suppress the development of small bowel inflammatory disease (PMID: 29262351); the lab has new R01-level funding to explore the T cell-intrinsic functions of ligand-operated nuclear receptors in T cell-bile acid cross-talk in the intestine.
The successful candidate will contribute to all aspects of the project, including both in vitro and in vivo T cell analyses, molecular cloning, retroviral T cell transduction experiments, as well as execution and analysis of high-content flow cytometry, RNA-seq, DNA-seq and ATAC-seq experiments.
The successful candidate will work in a fast-paced and dynamic group environment and will be supported by a full-time Senior Research Assistant.
For more information about the Sundrud lab, please visit www.sundrudlab.com.
About The Scripps Research Institute
The Scripps Research Institute, one of the world's largest, private, non-profit research organizations, stands at the forefront of basic biomedical science, a vital segment of medical research that seeks to comprehend the most fundamental processes of life. Over the last decades, the institute has established a lengthy track record of major contributions to the betterment of health and the human condition.